Our bodies release naturally-occurring opioids called endorphins in response to pleasurable activities, such as exercising and laughing. Endorphins are heavily involved in reward pathways, causing us to seek out experiences that cause endorphin release. Alcohol has been shown to cause a release of endorphins, creating a cycle of use and addiction. Alcohol has also been shown to cause a higher release of endorphins in people who may be more susceptible to addictions, such as people with a family history of alcohol use disorder. Naltrexone works by blocking opioid receptors, the same receptors that endorphins act on. Taking naltrexone before you drink reduces the pleasurable effects of alcohol, otherwise known as the "buzz" from drinking alcohol. This essentially causes your brain to lose interest in alcohol, as it decreases the cycle of reward associated with alcohol use.